Estimation of Reservoir Porosity Using Seismic Post-Stack Inversion in Lower Indus Basin, Pakistan

Seismic post-stack inversion is one of the best techniques for effective reservoir characterization. This study intends to articulate the application of Model-Based Inversion (MBI) and Probabilistic Neural Networks (PNN) for the identification of reservoir properties i.e. porosity estimation. MBI technique is applied to observe the low impedance zone at the porous reservoir formation. PNN is a geostatistical technique that transforms the impedance volume into porosity volume. Inverted porosity is estimated to observe the spatial distribution of porosity in the Lower Goru sand reservoir beyond the well data control. The result of inverted porosity is compared with that of well-computed porosity. The estimated inverted porosity ranges from 13-13.5% which shows a correlation of 99.63% with the computed porosity of the Rehmat-02 well. The observed low impedance and high porosity cube at the targeted horizon suggest that it could be a probable potential sand channel. Furthermore, the results of seismic post-stack inversion and geostatistical analysis indicate a very good agreement with each other. Hence, the seismic post-stack inversion technique can effectively be applied to estimate the reservoir properties for further prospective zones identification, volumetric estimation and future exploration

Evaluation of Gas Potential in Early Cretaceous Shale Lower Indus Basin, Pakistan

The shale gas potential of the early Cretaceous Talhar shale member of the lower Goru Formation in lower Indus basin of Sanghar district, Sindh province, has been evaluated using 2D seismic and well logs data. Graphical and empirical techniques were applied to calculate various geochemical parameters for the evaluation of shale plays. Total Organic Carbon (TOC) is calculated by Passey's (∆LogR) Overlay technique and its values are about 2.44 wt.%. Vitrinite Reflectance (Ro) is estimated by graphical and empirical relation and the value lies between 0.95-1.0 which implies that the Talhar shale member is in peak oil and initial gas generation phase. Log-derived Maturity Index (LMI) is calculated by NPHI, RHOB or density log and uranium logs. The average value is about 0.55 which reflects that the formation is probably in the initial maturation phase. Kerogen Volume (Vk) is estimated by empirical relation using RHOB log as input and it is about 13 wt. % which reflects that the formation has enough potential of oil/gas expulsion. The results are compared and validated with a study of the adjacent field of the same basin. This study reveals that Talhar member of lower Goru Formation could be the future probable potential unconventional reservoir for exploration in lower Indus basin of Pakistan

A clinical study of arrhythmias associated with acute coronary syndrome: a hospital based study of a high risk and previously undocumented population

Background: ACS represents a global epidemic. Arrhythmia in ACS is common. Careful investigation may lead to further improvement of prognosis. Retrospectively analyzed the year- round data of our center. Study was undertaken to analyze the incidence, frequency and type of arrhythmias in ACS. This is to aid timely intervention and to modify the outcome. Identification of the type of arrhythmia is of therapeutic and prognostic importance.Methods: This cross sectional analytical study was conducted in the Department of Cardiology, Apollo Hospitals Dhaka, from January 2019 to January 2020 with ACS patients. Enrolled consecutively and data analyzed.Results: There were 500 patients enrolled considering inclusion and exclusion criteria. Sample was subdivided into 3 groups on the type of ACS. Group-I with UA, Group-II with NSTE - ACS and Group-III with STE - ACS. Different types of arrhythmia noted. Types of arrhythmia were correlated with type of ACS. 500 patients included. Mean age 55.53±12.70, 71.6% male and 28.4% female. 60.4% hypertensive, 46.2% diabetic, 20.2% positive family history of CAD, 32.2% current smoker, 56.4% dyslipidaemic and 9.6% asthmatic. 31.2% UA, 39.2% NSTE-ACS and 29.6% STE-ACS. Type of arrhythmias noted. 22% sinus tachycardia, 20.2% sinus bradycardia, 9% atrial fibrillation, 5.2% ventricular ectopic, 4.8% supra ventricular ectopic, 2.8% bundle branch block, 2.2% atrio-ventricular block, 1% broad complex tachycardia, 0.4% narrow complex tachycardia, 0.2% sinus node dysfunction and 32.2% without any arrhythmia. Significant incidences of arrhythmia detected - respectively 29.8%, 39.2% and 31%, p<0.001.Conclusions: In conclusion, arrhythmias in ACS are common. More attention should be paid to improve their treatment and prognosis

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Pyogenic liver abscess: Changing patterns in approach

AIM: To define optimum management of the pyogenic liver abscess and assess new trends in treatment

Lineament mapping for a part of the Central Sulaiman Fold–Thrust Belt (SFTB), Pakistan

&lt;jats:title&gt;Abstract&lt;/jats:title&gt;&lt;jats:p&gt;This study aims to analyze the lineaments using the field data and a remote sensing approach, to describe their relationship with the folds, faults, and regional tectonic stress of the central Sulaiman Fold-Thrust Belt. Joint data, from nine anticlines, has been collected using the scanline method and classified into three sets (JS1, JS2, and JS3) based on their geometrical relationships. Lineaments extracted from the 30 m digital elevation model have been classified subsequently into three lineament sets (LS1, LS2, and LS3) based on the azimuths from the corresponding joint sets. A very high correlation coefficient (rs = 0.97), between the azimuths of the field joints and the remotely sensed lineaments, has been observed which validates that the lineaments are the regional representation of the local field joints. The geometrical relationship of the lineament sets with the fold hinges indicates that the older LS1 and LS2 are strongly related to the regional folding episode, while the younger LS3 is a result of local shears. The chronological interpretation of the deformational events responsible for the lineament sets is constrained by the presence of the Kingri Fault, which induces a strike-slip component within the study area. Furthermore, the controls on the joint and lineament sets, established using multivariate statistics to decipher the effects of lithological and structural contrasts on the lineament density, reveal that an increase in the lineament density can be attributed to the competence and thickness of the rock units as well as the variable local stresses across the different folds. Based on the orientations of these lineament sets, the cumulative direction of the compressive event in the NW-SE direction (310–320) coincides with the regional stress direction of the SFTB.&lt;/jats:p&gt

Effect of Reynolds numbers on flow past four square cylinders in an in-line square configuration for different gap spacings

In this paper two-dimensional (2-D) numerical investigation of flow past four square cylinders in an in-line square configuration are performed using the lattice Boltzmann method. The gap spacing g=s/d is set at 1, 3 and 6 and Reynolds number ranging from Re=60 to 175. We observed four distinct wake patterns: (i) a steady wake pattern (Re=60 and g=1) (ii) a stable shielding wake pattern (80≤Re≤175 and g=1) (iii) a wiggling shielding wake pattern (60≤Re≤175 and g=3) (iv) a vortex shedding wake pattern (60≤Re≤175 and g=6) At g=1, the Reynolds number is observed to have a strong effect on the wake patterns. It is also found that at g=1, the secondary cylinder interaction frequency significantly contributes for drag and lift coefficients signal. It is found that the primary vortex shedding frequency dominates the flow and the role of secondary cylinder interaction frequency almost vanish at g=6. It is observed that the jet between the gaps strongly influenced the wake interaction for different gap spacing and Reynolds number combination. To fully understand the wake transformations the details vorticity contour visualization, power spectra of lift coefficient signal and time signal analysis of drag and lift coefficients also presented in this paper